Author(s): Tóthová Csilla, Nagy O, Seidel H, Kováč G
Keywords:calves, enzymes, haptoglobin, injections, serum amyloid A
The objective of this study was to evaluate the possible effects of various forms of injections of a combined mineral preparation in calves on changes in serum concentrations of selected acute phase proteins – haptoglobin (Hp) and serum amyloid A (SAA), as well as on changes in the activity of selected enzymes – creatine kinase (CK) and aspartate amino-transferase (AST). The changes in serum concentrations and activities of the aforementioned variables were evaluated after administration of the recommended therapeutic dose of the mentioned preparation and its repeated administration, and compared with changes recorded after a double therapeutic dose and its repeated administration. Analyses showed a more marked increase of mean SAA concentrations after intramuscular and subcutaneous injections of the higher preparation dose. A gradual insignificant increase in Hp serum concentrations was observed. The most significant changes were recorded in increasing serum activities of CK and AST after intramuscular injections of higher dose of the remedy (P<0.001 and P<0.01, respectively). Presented results indicate that tissue injury and muscle damage caused by repeated injections, predominantly at higher doses of drugs, may result not only in increased activities of some enzymes, but also in more marked changes in serum concentrations of certain acute phase proteins, particularly serum amyloid A.
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