Volume 66 (2016) Issue: 2016 No#4

In vivo enzymes activities of some Ru(II) compounds with N-alkylphenothiazines

Author(s): Krstić Milena, Borozan Sunčica, Sovilj Sofija, Grgurić-Šipka Sanja, Poljarević Jelena

Keywords:Ruthenium complexes; N-alkylphenothiazines; Acethylcholinesterase; Lactate dehydrogenase

The purpose of the present study was to investigate and compare the effects of two ruthenium complexes with trifluoperazine on acethylcholinesterase enzyme activity and lactate dehydrogenase levels in vivo under physiological conditions in rats blood. Complexes 1 and 2 showed positive effects on acethylcholinesterase at all doses and did not disturb its normal activity. Total LDH activity was inhibited in the presence of both complexes, but Ru(II) complexes showed different effects on the activity of LDH isoenzymes. The activities of LDH1 and LDH2 isoenzymes were decreased in all applied doses of the complex 2, while the activity of LDH2 reduced using complex 1 in the same doses. Results of the present study suggest the neuro- and cardio protective potential of oral administration of complexes 1 and 2, as non-toxic compounds under physiological conditions. These protective effects are the result of their potent antioxidant activity.


My account

Search


Info

ISSN: 0567-8315

eISSN: 1820-7448

Indexing: Thomson Reuters/Science Citation Index Expanded, Zoological Record, Biosis Previews, Web of Science, Journal Citation Reports, Google Scholar, SCIndeks, KoBSON, Genamics, Journal Seek, Research Gate, DOAJ, Journal Rate, SJR – SCImago Journal & Country Rank, WorldCat, Academic Journals Database, Medical Journals Links, MedSci, Pubget

Contribute