Volume 58 (2008) Issue: 2008 No#2-3

Blood supply of the insular cortex on Ceropithecus Aethiops: another approach to establish non-human primate model for addiction

Author(s): Filipović B, Dimitrijević I, Đulejić V, Krstić M, Jurišić A, Kalezić Nevena, Teofilovski- Parapid Gordana

Keywords:insula, blood supply, Cercopithecus Aethiops, addiction, non-human primate model

The non-human primate model has already been applied in studies about alcoholism in the last decade, demonstrating a high confidence level of similarities between humans and non-human monkeys. Authors indented to establish the definitive model for addiction by investigating the insular blood supply in Cercopithecus Aethiops. In 23 out of 24 Latex injected adult brains, the insula received blood supplied by the M2 segment of the middle cerebral artery (MCA). The cortex was supplied by two separate trunks, while perforating branches originating directly from MCA, individually, or together with lateral striate (lenticulostriate) arteries. Their average caliber was about 120 μm, and the number of its branches ranged from 2 to 9. No left – right asymmetries have been recorded. Similarities with the human vascular pattern have been studied.