Author(s): Nešković N, Gašić Slavica, Brkić Dragica, Pavlovski Zlatica, Cmiljanić R
Keywords:biochemistry, chickens, cypermethrin, hematology, toxic effects
In the following study effects of dietary cypermethrin in chickens were observed. Chickens were administered cypermethrin in the feed in nominal concentrations of 150, 300 and 600 ppm (mean measured concentrations: 130, 285 and 655 mg/kg feed) for a period of 28 days. The following parameters were monitored: clinical symptoms and mortality, feed consumption and body weight gain, liver weight, plasma ChE activity, hematological and biochemical effects. Any accumulation of cypermethrin in the liver, peritoneal fat, breast and leg muscle was monitored, as well. The results obtained showed that cypermethrin added to the chickens feed did not significantly affect feed intake, body weight gain and liver weight. Also, cypermethrin did not adversely affect the activity of plasma ChE and ALT in the serum. Serum AST activity was significantly increased in the treated chickens, in males at 300 and 600 ppm and in females at all three tested doses. ALP activity was significantly decreased in comparison with the control, in males at doses 300 and 600 ppm, but in females only at the dose of 600 ppm. Hematological data showed that cypermethrin induced a statistically significant increase only in PLT number (both sexes, all three doses tested). The obtained results also showed that cypermethrin did not accumulate in organs and tissues of chickens.
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