Author(s): Todorović Tatjana, Dožić I, Vujanović Dragana, Pejović J, Marjanović
Keywords:lead, hepatotoxicity, enzymes, AST, ALT, ALP
In this paper, the influence of chronic lead intoxication on the activity of serum enzymes aspartate and alanine aminotransferases (AST and ALT) and alkaline phosphatase (ALP) was examined. The experiment was performed on 130 adult female DA rats and 80 young rats. Rats were treated by lead-acetate 100 and 30 mg Pb per kg body weight for 10, 20, 30, 40, 50 and 60 days. Young rats (offspring of studied female rats) were treated with lead only through the placenta and mother's milk. The activities of serum AST, ALT and ALP were determined spectrophotomerically by IFCC method. The activity of examined serum enzymes was significantly increased in conditions of chronic lead intoxication in female rats and their offspring in relation to the control group. The activity of serum AST, ALT and ALP was in a positive correlation with the time of intoxication. There were no significant differences between the activities of enzymes AST and ALT in the serum and the amount of lead. The activity of ALP was significantly higher in serum of rats treated with higher amounts of lead. Increased AST, ALT and ALP activity in serum is most likely the consequence of lead hepatotoxicity.
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