Volume 56 (2006) Issue: 2006 No#2-3

L-arginine and physostigmine in hemorrhagic shock: lack of evidence for synergism

Author(s): Gopčević Kristina, Gojgić-Cvijović Gordana, Pavlović Mirjana, Milićević Živana, Stevanović D

Keywords:ionophores, myocardium, inotropic

The effect of some membrane active ionophoric antibiotics on the amplitude of contractions of isolated rat heart right ventricle was studied. The effects of polyether nigericin, polyene amphotericin B and peptide antibiotic polymyxin B were examined. Nigericin in a concentration of 1.38 mol/L exerts a positive inotropic effect with its maximal value (+29%) 15 minutes after application. Amphotericin B in a concentration of 1.08 mol/L caused a positive inotropic effect, which was maximal in the 30th minute of the experiment (+28%). Polymyxin B in a concentration of 0.84 mol/L caused a positive inotropic effect, which was maximal (+32%) 20 minutes after application.


My account

Search


Info

ISSN: 0567-8315

eISSN: 1820-7448

Indexing: Thomson Reuters/Science Citation Index Expanded, Zoological Record, Biosis Previews, Web of Science, Journal Citation Reports, Google Scholar, SCIndeks, KoBSON, Genamics, Journal Seek, Research Gate, DOAJ, Journal Rate, SJR – SCImago Journal & Country Rank, WorldCat, Academic Journals Database, Medical Journals Links, MedSci, Pubget

Contribute